| Title: |
Early combination therapy with hydroxychloroquine and azithromycin reduces mortality in 10,429 COVID-19 outpatients. |
| Authors: |
MILLION, Matthieu, LAGIER, Jean-Christophe, TISSOT-DUPONT, Hervé, RAVAUX, Isabelle, DHIVER, Catherine, TOMEI, Christelle, CASSIR, Nadim, DELORME, Léa, CORTAREDONA, Sébastien, AMRANE, Sophie, AUBRY, Camille, BENDAMARDJI, Karim, BERENGER, Cyril, DOUDIER, Barbara, EDOUARD, Sophie, HOCQUART, Marie, MAILHE, Morgane, PORCHETO, Coralie, SENG, Piseth, TRIQUET, Catherine |
| Source: |
Reviews in Cardiovascular Medicine; Sep2021, Vol. 22 Issue 3, p1063-1072, 10p |
| Abstract: |
We evaluated the age-specific mortality of unselected adult outpatients infected with SARS-CoV-2 treated early in a dedicated COVID-19 day hospital and we assessed whether the use of hydroxychloroquine (HCQ) + azithromycin (AZ) was associated with improved survival in this cohort. A retrospective monocentric cohort study was conducted in the day hospital of our center from March to December 2020 in adults with PCR-proven infection who were treated as outpatients with a standardized protocol. The primary endpoint was 6-week mortality, and secondary endpoints were transfer to the intensive care unit and hospitalization rate. Among 10,429 patients (median age, 45 [IQR 32-57] years; 5597 [53.7%] women), 16 died (0.15%). The infection fatality rate was 0.06% among the 8315 patients treated with HCQ+AZ. No deaths occurred among the 8414 patients younger than 60 years. Older age and male sex were associated with a higher risk of death, ICU transfer, and hospitalization. Treatment with HCQ+AZ (0.17 [0.06-0.48]) was associated with a lower risk of death, independently of age, sex and epidemic period. Meta-analysis evidenced consistency with 4 previous outpatient studies (32,124 patients-Odds ratio 0.31 [0.20-0.47], I2 = 0%). Early ambulatory treatment of COVID-19 with HCQ+AZ as a standard of care is associated with very low mortality, and HCQ+AZ improve COVID-19 survival compared to other regimens. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
