| Title: |
Factors associated with quality of life in Italian children and adolescents with IBD. |
| Authors: |
Gatti, Simona, Del Baldo, Giada, Catassi, Giulia, Faragalli, Andrea, Aloi, Marina, Bramuzzo, Matteo, D'Arcangelo, Giulia, Felici, Enrico, Fuoti, Maurizio, Lega, Sara, Panceri, Roberto, Pastore, Maria, Penagini, Francesca, Gesuita, Rosaria, Catassi, Carlo |
| Source: |
Scientific Reports; 9/10/2021, Vol. 11 Issue 1, p1-9, 9p |
| Subject Terms: |
QUALITY of life, INFLAMMATORY bowel diseases, EMOTIONS, STATISTICAL correlation |
| Geographic Terms: |
ITALY |
| Abstract: |
Improving the quality of life (QoL) is crucial in the management of pediatric inflammatory bowel disease (IBD). We aimed to (1) Validate the IMPACT-III questionnaire in Italian IBD children; (2) explore factors associated to QoL in pediatric IBD. Internal consistency, concurrent validity, discriminant validity and reproducibility of the Italian version of the IMPACT-III questionnaire was measured in IBD children/adolescents in 8 centers. Associations between patient and disease characteristics and the IMPACT-III domains were analyzed through quantile regression analysis. The IMPACT-III questionnaire, collected in 282 children with IBD (median age: 14.8 years; IQR 12.4–16.4) showed a median total score of 76 (IQR 67–83). Female gender, active disease and age were negatively associated with the total IMPACT-III score. Specifically, female gender was negatively associated with the Bowel/Systemic Symptoms, Emotional and Treatment domain scores, while disease activity was significantly associated with Bowel Symptoms and Treatment/Interventions reported QoL. The IMPACT- III showed good internal consistency (Cronbach's alpha coefficient = 0.87, 95% CI 0.85–0.89) and reproducibility (Concordance Correlation Coefficient = 0.66, 95% CI 0.57–0.74). In Italian children with IBD active disease, female gender and adolescence are associated to a worse QoL, indicating the need of more attention in this subgroup of young patients. IMPACT-III questionnaire is a reliable instrument to measure QoL in Italian children. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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