Bibliographic Details
| Title: |
The updated five-year overall survival and long-term oxaliplatin-related neurotoxicity assessment of the FACOS study. |
| Authors: |
Takeshita, Emiko, Ishibashi, Keiichiro, Koda, Keiji, Oda, Noritaka, Yoshimatsu, Kazuhiko, Sato, Yu, Oya, Masatoshi, Yamaguchi, Satoru, Nakajima, Hideo, Momma, Tomoyuki, Maekawa, Hiroshi, Tsubaki, Masahiro, Yamada, Takeshi, Kobayashi, Michiya, Tanakaya, Kohji, Ishida, Hideyuki |
| Source: |
Surgery Today; Aug2021, Vol. 51 Issue 8, p1309-1319, 11p |
| Subject Terms: |
OVERALL survival, COLON cancer, NEUROTOXICOLOGY, ADJUVANT chemotherapy, JAPANESE people |
| Abstract: |
Purpose: We previously reported the first evidence of oncological benefits from a Japanese phase II trial of oxaliplatin-based adjuvant chemotherapy in patients with stage III colon cancer (the FACOS study). We herein report the long-term survival and persistent oxaliplatin-related peripheral sensory neuropathy (PSN) for patients enrolled in this trial. Methods: Patients were scheduled to receive the mFOLFOX6 or CAPOX regimen in the adjuvant setting. The five-year overall survival (OS) rate and persistent PSN were evaluated. Results: A total of 130 patients (mFOLFOX6, n = 73; CAPOX, n = 57) were eligible. The 5-year OS rate was 91.4%. No significant difference in the OS rate was observed between regimens (mFOLFOX6, 94.4%; CAPOX, 87.4%; P = 0.25). The incidence of PSN during adjuvant treatment was 55.4% in grade 1 (G1), 30.0% in G2, and 4.6% in G3. No patients showed G3 PSN at 12 months, but G1 or G2 residual PSN after 5 years was observed in 21.8% (G1, 20%; G2, 1.8%). Conclusions: Updated results from the FACOS study support the benefits of oxaliplatin-based adjuvant chemotherapy in terms of the long-term survival among Japanese patients with stage III colon cancer. However, long-term persistent PSN occurs in about 20% of survivors, counterbalancing the favorable OS. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
