| Title: |
Major Depressive Disorder in Older Patients as an Inflammatory Disorder: Implications for the Pharmacological Management of Geriatric Depression. |
| Authors: |
Forbes, Malcolm P., O'Neil, Adrienne, Lane, Melissa, Agustini, Bruno, Myles, Nick, Berk, Michael |
| Source: |
Drugs & Aging; Jun2021, Vol. 38 Issue 6, p451-467, 17p |
| Subject Terms: |
MENTAL depression risk factors, BIOMARKERS, INFLAMMATION, ANTI-inflammatory agents, MENTAL depression, DISEASE prevalence, DISEASE complications, OLD age |
| Abstract: |
Depression is a common and highly disabling condition in older adults. It is a heterogenous disorder and there is emerging evidence of a link between inflammation and depression in older patients, with a possible inflammatory subtype of depression. Persistent low-level inflammation, from several sources including psychological distress and chronic disease, can disrupt monoaminergic and glutaminergic systems to create dysfunctional brain networks. Despite the evidence for the role of inflammation in depression, there is insufficient evidence to recommend use of any putative anti-inflammatory agent in the treatment of depression in older adults at this stage. Further characterisation of markers of inflammation and stratification of participants with elevated rates of inflammatory markers in treatment trials is needed. [ABSTRACT FROM AUTHOR] |
|
Copyright of Drugs & Aging is the property of Springer Nature and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
