Bibliographic Details
| Title: |
Racial/ethnic differences in anthropometric and hormone-related factors and endometrial cancer risk: the Multiethnic Cohort Study. |
| Authors: |
Sarink, Danja, Wilkens, Lynne R., White, Kami K., Le Marchand, Loïc, Wu, Anna H., Setiawan, V. Wendy, Park, S. Lani, Park, Song-Yi, Killeen, Jeffrey L., Merritt, Melissa A. |
| Source: |
British Journal of Cancer; May2021, Vol. 124 Issue 10, p1724-1733, 10p |
| Abstract: |
Background: Anthropometric and hormone-related factors are established endometrial cancer risk factors; however, little is known about the impact of these factors on endometrial cancer risk in non-White women.Methods: Among 110,712 women participating in the Multiethnic Cohort (MEC) Study, 1150 incident invasive endometrial cancers were diagnosed. Hazard ratios (HRs) and 95% confidence intervals (CIs) for associations with endometrial cancer risk for race/ethnicity and for risk factors across racial/ethnic groups were calculated.Results: Having a higher body mass index (BMI) at baseline or age 21 years was strongly associated with increased risk (pint race/ethnicity ≥ 0.36). Parity (vs nulliparity) was inversely associated with risk in all the groups except African Americans (pint 0.006). Current use of postmenopausal hormones at baseline (PMH-E; vs never use) was associated with increased risk in Whites and Japanese Americans (pint 0.002). Relative to Whites, endometrial cancer risk was lower in Japanese Americans and Latinas and non-significantly higher in Native Hawaiians. Risk in African Americans did not differ from that in Whites.Conclusions: Racial/ethnic differences in endometrial cancer risk were not fully explained by anthropometric or hormone-related risk factors. Further studies are needed to identify reasons for the observed racial/ethnic differences in endometrial cancer risk. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
