Bibliographic Details
| Title: |
5-Fluorouracil: A Narrative Review on the Role of Regulatory Mechanisms in Driving Resistance to This Chemotherapeutic Agent. |
| Authors: |
Ghafouri-Fard, Soudeh, Abak, Atefe, Tondro Anamag, Farhad, Shoorei, Hamed, Fattahi, Faranak, Javadinia, Seyed Alireza, Basiri, Abbas, Taheri, Mohammad |
| Source: |
Frontiers in Oncology; 4/19/2021, Vol. 11, pN.PAG-N.PAG, 21p |
| Subject Terms: |
LINCRNA, CANCER chemotherapy, FLUOROURACIL, NON-coding RNA, EPITHELIAL-mesenchymal transition |
| Abstract: |
5-fluorouracil (5-FU) is among the mostly administrated chemotherapeutic agents for a wide variety of neoplasms. Non-coding RNAs have a central impact on the determination of the response of patients to 5-FU. These transcripts via modulation of cancer-related pathways, cell apoptosis, autophagy, epithelial–mesenchymal transition, and other aspects of cell behavior can affect cell response to 5-FU. Modulation of expression levels of microRNAs or long non-coding RNAs may be a suitable approach to sensitize tumor cells to 5-FU treatment via modulating multiple biological signaling pathways such as Hippo/YAP, Wnt/β-catenin, Hedgehog, NF-kB, and Notch cascades. Moreover, there is an increasing interest in targeting these transcripts in various kinds of cancers that are treated by 5-FU. In the present article, we provide a review of the function of non-coding transcripts in the modulation of response of neoplastic cells to 5-FU. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
