Bibliographic Details
| Title: |
In vitro pharmacodynamics of omadacycline against Escherichia coli and Acinetobacter baumannii. |
| Authors: |
Noel, A R, Attwood, M, Bowker, K E, MacGowan, A P |
| Source: |
Journal of Antimicrobial Chemotherapy (JAC); Mar2021, Vol. 76 Issue 3, p667-670, 4p |
| Abstract: |
Background: The pharmacodynamics of omadacycline have been extensively studied against Gram-positive pathogens but less information is available for Gram-negative pathogens. We describe the pre-clinical pharmacodynamics of omadacycline against Escherichia coli and Acinetobacter baumannii.Methods: An in vitro dilutional pharmacokinetic model was used. Exposure experiments with fAUC/MIC ratios ranging from 0 to 1200 were performed using five strains of E. coli and five strains of A. baumannii. Reduction in bacterial load and changes in population profiles were measured.Results: The fAUC/MIC targets against E. coli for 24 h static and -1 log reduction in load were 25.3 ± 17.2 and 42.7 ± 32.5, respectively. For A. baumannii the fAUC/MIC for 24 h static effect was 108.1 ± 38.6. Changes in population profiles were observed for E. coli at fAUC/MIC ratios of ≤200 and for A. baumannii up to 1200. MICs were increased 2-32 fold.Conclusions: fAUC/MIC targets for A. baumannii are greater than for E.coli and changes in population profiles more likely. E. coli fAUC/MIC targets align with in vivo data and will be useful in determining omadacycline dosing for this pathogen. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
