Bibliographic Details
| Title: |
Future directions in advanced penile cancer - mechanisms of carcinogenesis and a search for targeted therapy. |
| Authors: |
Teh, Jiasian, O'Connor, Ellen, O'Brien, Jonathon, Lim, Wei Mou, Taylor, Michael, Heriot, Alexander, Ramsay, Robert, Lawrentschuk, Nathan |
| Source: |
Future Oncology; Oct2020, Vol. 16 Issue 29, p2357-2369, 13p |
| Abstract: |
Penile squamous cell carcinoma (SCC) is a rare and aggressive urological malignancy. Advanced penile SCC requires multimodal management, including surgery and systemic therapy. Given its rarity, there have been few substantial advances in our understanding of the molecular and genomic drivers of penile SCC, especially for patients with relapsed or advanced disease. In this review, we discuss the molecular and genomic landscape of penile SCC, clinical trials in progress and implications for novel therapeutic targets. Future work should focus on preclinical models to provide a platform for investigation and validation of new molecular pathways for testing of therapeutics. [ABSTRACT FROM AUTHOR] |
|
Copyright of Future Oncology is the property of Future Medicine Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Complementary Index |
