Bibliographic Details
| Title: |
Defining the CD39/CD73 Axis in SARS-CoV-2 Infection: The CD73- Phenotype Identifies Polyfunctional Cytotoxic Lymphocytes. |
| Authors: |
Ahmadi, Parimah, Hartjen, Philip, Kohsar, Matin, Kummer, Silke, Schmiedel, Stefan, Bockmann, Jan-Hendrik, Fathi, Anahita, Huber, Samuel, Haag, Friedrich, Schulze zur Wiesch, Julian |
| Source: |
Cells (2073-4409); Aug2020, Vol. 9 Issue 8, p1750, 1p |
| Subject Terms: |
CYTOTOXIC T cells, SARS-CoV-2, LYMPHOCYTES, TUMOR necrosis factors, COVID-19, T cells |
| Abstract: |
The ectonucleotidases CD39 and CD73 regulate immune responses by balancing extracellular ATP and adenosine in inflammation and are likely to be involved in the pathophysiology of COVID-19. Here, we analyzed CD39 and CD73 on different lymphocyte populations in a small cohort of COVID-19 patients and in healthy individuals. We describe a significantly lower level of expression of CD73 on cytotoxic lymphocyte populations, including CD8+ T, natural killer T (NKT), and natural killer (NK) cells, during COVID-19. Interestingly, the decrease of CD73 on CD8+ T cells and NKT cells correlated with serum ferritin levels. Furthermore, we observed distinct functional differences between the CD73+ and CD73- subsets of CD8+ T cells and NKT cells with regard to cytokine/toxin secretion. In COVID-19 patients, the majority of the CD73-CD8+ T cells were capable of secreting granzyme B, perforin, tumor necrosis factor (TNF-α) or interferon-gamma (IFN-γ). To conclude, in this first study of CD39 and CD73 expression of lymphocytes in COVID-19, we show that CD8+ T cells and NKT cells lacking CD73 possess a significantly higher cytotoxic effector functionality compared to their CD73+ counterparts. Future studies should investigate differences of cellular CD39 and CD73 expression in patients at different disease stages and their potential as prognostic markers or targets for immunomodulatory therapies. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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