Bibliographic Details
| Title: |
Omega-3 fatty acids and anxiety: A systematic review of the possible mechanisms at play. |
| Authors: |
Polokowski, Ashley R., Shakil, Haque, Carmichael, Cheryl L., Reigada, Laura C. |
| Source: |
Nutritional Neuroscience; Jul2020, Vol. 23 Issue 7, p494-504, 11p, 2 Charts |
| Subject Terms: |
BRAIN-derived neurotrophic factor, INFLAMMATION, META-analysis, OMEGA-6 fatty acids, ANXIETY, MENTAL illness, MENTAL health, OMEGA-3 fatty acids |
| Abstract: |
Introduction: Anxiety is prevalent, costly, and associated with significant adverse outcomes. The importance of nutrition is underestimated in the management of mental health disorders. In particular, omega-3 fatty acids (ω-3 FAs) are a critical component for healthy development and have been shown to reduce anxiety symptoms. Objective: This paper reviews the current state of the research to identify potential mechanisms underlying the relationship between ω-3 FAs and anxiety reduction. Method: Studies were identified using PubMed, PsycINFO, and CINAHL databases. Results: Of the 197 full-text studies screened, six met criteria for inclusion. Four mechanisms were identified based on primary outcomes reported by each study, Inflammatory Response, Brain-Derived Neurotrophic Factor (BDNF), Cortisol, and Cardiovascular Activity.Conclusion:Five key recommendations are provided to guide future research examining ω-3 FAs and anxiety. They include: (1) standardization of dosage and duration of ω-3 supplementation, (2) more rigorous measurement of variables, (3) effective blinding of participants, (4) designing experiments that test mediation, and (5) increasing sample diversity. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
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