Bibliographic Details
| Title: |
Hemophagocytic Lymphohistiocytosis in a Patient With Nodular Lymphocyte-Predominant Hodgkin Lymphoma: A Case Report. |
| Authors: |
Ahmad, Delshad, Akkad, Mohamed, Olsen, Brian, Al-Janadi, Anas |
| Source: |
American Journal of Hematology/Oncology; Feb2017, Vol. 13 Issue 2, p4-8, 5p |
| Subject Terms: |
HODGKIN'S disease, IMMUNOTHERAPY, PHAGOCYTOSIS, NON-langerhans-cell histiocytosis, SYMPTOMS |
| Abstract: |
Hemophagocytic lymphohistiocytosis (HLH) is a rare and rapidly progressing clinical syndrome with unknown incidence in adults that results from severe immune activation. Characteristic findings include fever, hepatosplenomegaly, lymphadenopathy, pancytopenia, rash, and neurological symptoms with elevated triglycerides, ferritin, and hypofibrinogenemia. HLH is often described as primary hemophagocytic lymphohistiocytosis (inherited), with underlying genetic abnormality, or secondary (acquired) to another underlying condition such as a viral infection, an autoimmune disease, or a malignancy. To the best of our knowledge, this is the first case report of HLH complicating a nodular lymphocyte-predominant Hodgkin lymphoma (NLPHL) in an adult treated with rituximab, cyclophosphamide, doxorubicin, vincristine, and prednisone. The NLPHL showed the additional, unusual feature of cyclin D1 expression, which, to our knowledge, also has not been previously reported. The patient died after treatment failure following 3 regimens of therapy. High clinical suspicion of HLH should prompt immediate immunochemotherapy to reverse the otherwise high likelihood of a fatal outcome. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
