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Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV.

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Title: Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV.
Authors: Teeraananchai, Sirinya, Kerr, Stephen J, Gandhi, Monica, Do, Viet Chau, Nguyen, Lam Van, Tran, Dan Ngoc Hanh, Kosalaraksa, Pope, Singtoroj, Thida, Thammajaruk, Narukjaporn, Jupimai, Thidarat, Sohn, Annette H
Source: Journal of the Pediatric Infectious Diseases Society; Jun2020, Vol. 9 Issue 2, p253-256, 4p
Subject Terms: DRUGS, HIV infections, GENETIC mutation, PATIENT compliance, RISK assessment, PROTEASE inhibitors, VIRAL load, ANTIRETROVIRAL agents, TREATMENT effectiveness, ADOLESCENCE, CHILDREN
Geographic Terms: ASIA
Abstract: Of 56 children with perinatally acquired human immunodeficiency virus (HIV) who had been prescribed second-line protease inhibitor–based antiretroviral therapy and had ≥1 previous episode of viral failure (HIV RNA, ≥1000 copies/mL), 46% had ≥1, 34% had ≥2, and 23% had ≥3 consecutive episodes of viral failure during the 2 years of follow-up. Two of these children experienced a major protease inhibitor mutation. [ABSTRACT FROM AUTHOR]
Copyright of Journal of the Pediatric Infectious Diseases Society is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)
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  Label: Title
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  Data: Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV.
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  Data: <searchLink fieldCode="AR" term="%22Teeraananchai%2C+Sirinya%22">Teeraananchai, Sirinya</searchLink><br /><searchLink fieldCode="AR" term="%22Kerr%2C+Stephen+J%22">Kerr, Stephen J</searchLink><br /><searchLink fieldCode="AR" term="%22Gandhi%2C+Monica%22">Gandhi, Monica</searchLink><br /><searchLink fieldCode="AR" term="%22Do%2C+Viet+Chau%22">Do, Viet Chau</searchLink><br /><searchLink fieldCode="AR" term="%22Nguyen%2C+Lam+Van%22">Nguyen, Lam Van</searchLink><br /><searchLink fieldCode="AR" term="%22Tran%2C+Dan+Ngoc+Hanh%22">Tran, Dan Ngoc Hanh</searchLink><br /><searchLink fieldCode="AR" term="%22Kosalaraksa%2C+Pope%22">Kosalaraksa, Pope</searchLink><br /><searchLink fieldCode="AR" term="%22Singtoroj%2C+Thida%22">Singtoroj, Thida</searchLink><br /><searchLink fieldCode="AR" term="%22Thammajaruk%2C+Narukjaporn%22">Thammajaruk, Narukjaporn</searchLink><br /><searchLink fieldCode="AR" term="%22Jupimai%2C+Thidarat%22">Jupimai, Thidarat</searchLink><br /><searchLink fieldCode="AR" term="%22Sohn%2C+Annette+H%22">Sohn, Annette H</searchLink>
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  Data: Journal of the Pediatric Infectious Diseases Society; Jun2020, Vol. 9 Issue 2, p253-256, 4p
– Name: Subject
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  Data: <searchLink fieldCode="DE" term="%22DRUGS%22">DRUGS</searchLink><br /><searchLink fieldCode="DE" term="%22HIV+infections%22">HIV infections</searchLink><br /><searchLink fieldCode="DE" term="%22GENETIC+mutation%22">GENETIC mutation</searchLink><br /><searchLink fieldCode="DE" term="%22PATIENT+compliance%22">PATIENT compliance</searchLink><br /><searchLink fieldCode="DE" term="%22RISK+assessment%22">RISK assessment</searchLink><br /><searchLink fieldCode="DE" term="%22PROTEASE+inhibitors%22">PROTEASE inhibitors</searchLink><br /><searchLink fieldCode="DE" term="%22VIRAL+load%22">VIRAL load</searchLink><br /><searchLink fieldCode="DE" term="%22ANTIRETROVIRAL+agents%22">ANTIRETROVIRAL agents</searchLink><br /><searchLink fieldCode="DE" term="%22TREATMENT+effectiveness%22">TREATMENT effectiveness</searchLink><br /><searchLink fieldCode="DE" term="%22ADOLESCENCE%22">ADOLESCENCE</searchLink><br /><searchLink fieldCode="DE" term="%22CHILDREN%22">CHILDREN</searchLink>
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  Data: <searchLink fieldCode="DE" term="%22ASIA%22">ASIA</searchLink>
– Name: Abstract
  Label: Abstract
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  Data: Of 56 children with perinatally acquired human immunodeficiency virus (HIV) who had been prescribed second-line protease inhibitor–based antiretroviral therapy and had ≥1 previous episode of viral failure (HIV RNA, ≥1000 copies/mL), 46% had ≥1, 34% had ≥2, and 23% had ≥3 consecutive episodes of viral failure during the 2 years of follow-up. Two of these children experienced a major protease inhibitor mutation. [ABSTRACT FROM AUTHOR]
– Name: Abstract
  Label:
  Group: Ab
  Data: <i>Copyright of Journal of the Pediatric Infectious Diseases Society is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.)
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RecordInfo BibRecord:
  BibEntity:
    Identifiers:
      – Type: doi
        Value: 10.1093/jpids/piz034
    Languages:
      – Code: eng
        Text: English
    PhysicalDescription:
      Pagination:
        PageCount: 4
        StartPage: 253
    Subjects:
      – SubjectFull: ASIA
        Type: general
      – SubjectFull: DRUGS
        Type: general
      – SubjectFull: HIV infections
        Type: general
      – SubjectFull: GENETIC mutation
        Type: general
      – SubjectFull: PATIENT compliance
        Type: general
      – SubjectFull: RISK assessment
        Type: general
      – SubjectFull: PROTEASE inhibitors
        Type: general
      – SubjectFull: VIRAL load
        Type: general
      – SubjectFull: ANTIRETROVIRAL agents
        Type: general
      – SubjectFull: TREATMENT effectiveness
        Type: general
      – SubjectFull: ADOLESCENCE
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      – SubjectFull: CHILDREN
        Type: general
    Titles:
      – TitleFull: Determinants of Viral Resuppression or Persistent Virologic Failure After Initial Failure With Second-Line Antiretroviral Treatment Among Asian Children and Adolescents With HIV.
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            NameFull: Teeraananchai, Sirinya
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            – D: 01
              M: 06
              Text: Jun2020
              Type: published
              Y: 2020
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