Bibliographic Details
| Title: |
Amino-functionalized cellulose: a novel and high-efficiency scavenger for sodium cholate sorption. |
| Authors: |
Shen, Junyan, Yang, Xiaogang, Sun, Xiaoqing, Gong, Wenli, Ma, Yanan, Liu, Lin, Yao, Juming |
| Source: |
Cellulose; May2020, Vol. 27 Issue 7, p4019-4028, 10p |
| Subject Terms: |
SODIUM cholate, LANGMUIR isotherms, ADSORPTION capacity, SURFACE charges, ANTILIPEMIC agents, CELLULOSE synthase, SORPTION, CELLULOSE |
| Abstract: |
In this work, a novel and high-efficiency scavenger based on amino-functionalized cellulose was designed for sodium cholate sorption in vitro. To estimate the adsorption performance of the amino-functionalized cellulose for sodium cholate, various factors including sodium cholate concentration, contact time and electrolyte were investigated. The results suggested that amino-functionalization for cellulose regarding to hyperbranched polyethylenimine not only induce positive charge surface of cellulose but also provide abundant and special binding sites for sodium cholate sorption. The amino-functionalized cellulose displayed an excellent performance to sodium cholate sorption with a maximum adsorption capacity of 569.7 mg/g, higher than cholestyramine, a synthetic lipid-lowering drug in clinic. And the adsorption behavior was well fitted into the Langmuir isotherm model and pseudo-second-order kinetic model, suggesting a homogeneous monolayer chemisorption. Furthermore, the amino-functionalized cellulose presented the features of excellent anti-interferences, cytocompatibility and facile preparation process. All these results support amino-functionalized cellulose as a promising prospect for cholesterol elimination. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
