Bibliographic Details
| Title: |
Zika virus found in brain tissue of a multiple sclerosis patient undergoing an acute disseminated encephalomyelitis-like episode. |
| Authors: |
Alves-Leon, Soniza Vieira, Lima, Monique da Rocha, Nunes, Priscila Conrado Guerra, Chimelli, Leila Maria Cardão, Rabelo, Kíssila, Nogueira, Rita Maria Ribeiro, de Bruycker-Nogueira, Fernanda, de Azeredo, Elzinandes Leal, Bahia, Paulo Roberto, Rueda Lopes, Fernanda Cristina, Marcondes de Souza, Jorge P. Barreto, Fontes-Dantas, Fabrícia Lima, Paes, Marciano Viana, Lemos, Elba R. S., Santos, Flavia Barreto |
| Source: |
Multiple Sclerosis Journal; Mar2019, Vol. 25 Issue 3, p427-430, 4p, 1 Diagram |
| Subject Terms: |
IMMUNOTHERAPY, ZIKA virus, MULTIPLE sclerosis |
| Geographic Terms: |
BRAZIL |
| Abstract: |
Background: A range of different neurological manifestations has been reported in fetuses and adults after Zika virus (ZIKV) infection. Objective: We describe a detection of the ZIKV in the brain tissue from a multiple sclerosis (MS) patient with acute disseminated encephalomyelitis (ADEM)-like event in Rio de Janeiro, Brazil. Methods: Biological samples collected during the hospitalization were tested by serology and molecular diagnostic for various infectious agents. Histopathological analysis was performed using the anti-flavivirus group 4G2 monoclonal antibody, anti-ZIKV non-structural 1 (NS1) monoclonal antibody, and anti-CD4, CD8, and CD11b antibodies. Results: Anti-ZIKV IgM and IgG antibodies were positive in the serum and urine. A brain biopsy showed ZIKV protein in brain cells and T CD8 infiltration in brain tissue. Conclusion: Our data describe the coexistence of a recent central nervous system (CNS) ZIKV infection accompanied by a severe ADEM-like syndrome outcome in a patient with clinical history of MS. A de novo immune response concomitant with ZIKV infection might be involved in the mechanism of the ADEM-like syndrome and response to immunotherapy. The present report reinforces the importance of providing the differential diagnosis of acute episodes of MS exacerbation in an environment prone to ZIKV expression. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
