Impact of time to local recurrence on the occurrence of metastasis in breast cancer patients treated with neoadjuvant chemotherapy: A random forest survival approach.
| Title: | Impact of time to local recurrence on the occurrence of metastasis in breast cancer patients treated with neoadjuvant chemotherapy: A random forest survival approach. |
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| Authors: | Laas, Enora, Hamy, Anne-Sophie, Michel, Anne-Sophie, Panchbhaya, Nabilah, Faron, Matthieu, Lam, Thanh, Carrez, Sophie, Pierga, Jean-Yves, Rouzier, Roman, Lerebours, Florence, Feron, Jean-Guillaume, Reyal, Fabien |
| Source: | PLoS ONE; 1/23/2019, Vol. 14 Issue 1, p1-14, 14p |
| Subject Terms: | BREAST cancer prognosis, BREAST tumor treatment, CANCER relapse, CLINICAL trials, CANCER chemotherapy |
| Abstract: | Background: We studied the relationship between time to ipsilateral breast tumor recurrence (IBTR) and distant metastasis-free survival (DMFS) in patients with breast cancer treated by neoadjuvant chemotherapy (NAC). Methods: Between 2002 and 2012, 1199 patients with primary breast cancer were treated with NAC. Clinical, radiological and pathological data were retrieved from medical records. Multivariate analysis was performed with the random survival forest (RSF) method, to evaluate the relationship between time to local recurrence and DMFS. Results: Time to IBTR, local recurrence and molecular subtype were the factors most strongly associated with DMFS. In the total population, DMFS increased linearly with recurrence time, up to 50 months. For recurrences after 50 months, DMFS was similar for all times to recurrence. Considering molecular subtypes separately, the threshold was similar for the TNBC subtype (50 months), but appeared to occur later for the luminal and HER2-positive subtypes (75 months). Conclusion: A threshold of 50 months seems to differentiate between early and late recurrences and could be used to guide the medical management of local breast tumour recurrences. [ABSTRACT FROM AUTHOR] |
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| Database: | Complementary Index |
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| Items | – Name: Title Label: Title Group: Ti Data: Impact of time to local recurrence on the occurrence of metastasis in breast cancer patients treated with neoadjuvant chemotherapy: A random forest survival approach. – Name: Author Label: Authors Group: Au Data: <searchLink fieldCode="AR" term="%22Laas%2C+Enora%22">Laas, Enora</searchLink><br /><searchLink fieldCode="AR" term="%22Hamy%2C+Anne-Sophie%22">Hamy, Anne-Sophie</searchLink><br /><searchLink fieldCode="AR" term="%22Michel%2C+Anne-Sophie%22">Michel, Anne-Sophie</searchLink><br /><searchLink fieldCode="AR" term="%22Panchbhaya%2C+Nabilah%22">Panchbhaya, Nabilah</searchLink><br /><searchLink fieldCode="AR" term="%22Faron%2C+Matthieu%22">Faron, Matthieu</searchLink><br /><searchLink fieldCode="AR" term="%22Lam%2C+Thanh%22">Lam, Thanh</searchLink><br /><searchLink fieldCode="AR" term="%22Carrez%2C+Sophie%22">Carrez, Sophie</searchLink><br /><searchLink fieldCode="AR" term="%22Pierga%2C+Jean-Yves%22">Pierga, Jean-Yves</searchLink><br /><searchLink fieldCode="AR" term="%22Rouzier%2C+Roman%22">Rouzier, Roman</searchLink><br /><searchLink fieldCode="AR" term="%22Lerebours%2C+Florence%22">Lerebours, Florence</searchLink><br /><searchLink fieldCode="AR" term="%22Feron%2C+Jean-Guillaume%22">Feron, Jean-Guillaume</searchLink><br /><searchLink fieldCode="AR" term="%22Reyal%2C+Fabien%22">Reyal, Fabien</searchLink> – Name: TitleSource Label: Source Group: Src Data: PLoS ONE; 1/23/2019, Vol. 14 Issue 1, p1-14, 14p – Name: Subject Label: Subject Terms Group: Su Data: <searchLink fieldCode="DE" term="%22BREAST+cancer+prognosis%22">BREAST cancer prognosis</searchLink><br /><searchLink fieldCode="DE" term="%22BREAST+tumor+treatment%22">BREAST tumor treatment</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+relapse%22">CANCER relapse</searchLink><br /><searchLink fieldCode="DE" term="%22CLINICAL+trials%22">CLINICAL trials</searchLink><br /><searchLink fieldCode="DE" term="%22CANCER+chemotherapy%22">CANCER chemotherapy</searchLink> – Name: Abstract Label: Abstract Group: Ab Data: Background: We studied the relationship between time to ipsilateral breast tumor recurrence (IBTR) and distant metastasis-free survival (DMFS) in patients with breast cancer treated by neoadjuvant chemotherapy (NAC). Methods: Between 2002 and 2012, 1199 patients with primary breast cancer were treated with NAC. Clinical, radiological and pathological data were retrieved from medical records. Multivariate analysis was performed with the random survival forest (RSF) method, to evaluate the relationship between time to local recurrence and DMFS. Results: Time to IBTR, local recurrence and molecular subtype were the factors most strongly associated with DMFS. In the total population, DMFS increased linearly with recurrence time, up to 50 months. For recurrences after 50 months, DMFS was similar for all times to recurrence. Considering molecular subtypes separately, the threshold was similar for the TNBC subtype (50 months), but appeared to occur later for the luminal and HER2-positive subtypes (75 months). Conclusion: A threshold of 50 months seems to differentiate between early and late recurrences and could be used to guide the medical management of local breast tumour recurrences. [ABSTRACT FROM AUTHOR] – Name: Abstract Label: Group: Ab Data: <i>Copyright of PLoS ONE is the property of Public Library of Science and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract.</i> (Copyright applies to all Abstracts.) |
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| RecordInfo | BibRecord: BibEntity: Identifiers: – Type: doi Value: 10.1371/journal.pone.0208807 Languages: – Code: eng Text: English PhysicalDescription: Pagination: PageCount: 14 StartPage: 1 Subjects: – SubjectFull: BREAST cancer prognosis Type: general – SubjectFull: BREAST tumor treatment Type: general – SubjectFull: CANCER relapse Type: general – SubjectFull: CLINICAL trials Type: general – SubjectFull: CANCER chemotherapy Type: general Titles: – TitleFull: Impact of time to local recurrence on the occurrence of metastasis in breast cancer patients treated with neoadjuvant chemotherapy: A random forest survival approach. Type: main BibRelationships: HasContributorRelationships: – PersonEntity: Name: NameFull: Laas, Enora – PersonEntity: Name: NameFull: Hamy, Anne-Sophie – PersonEntity: Name: NameFull: Michel, Anne-Sophie – PersonEntity: Name: NameFull: Panchbhaya, Nabilah – PersonEntity: Name: NameFull: Faron, Matthieu – PersonEntity: Name: NameFull: Lam, Thanh – PersonEntity: Name: NameFull: Carrez, Sophie – PersonEntity: Name: NameFull: Pierga, Jean-Yves – PersonEntity: Name: NameFull: Rouzier, Roman – PersonEntity: Name: NameFull: Lerebours, Florence – PersonEntity: Name: NameFull: Feron, Jean-Guillaume – PersonEntity: Name: NameFull: Reyal, Fabien IsPartOfRelationships: – BibEntity: Dates: – D: 23 M: 01 Text: 1/23/2019 Type: published Y: 2019 Identifiers: – Type: issn-print Value: 19326203 Numbering: – Type: volume Value: 14 – Type: issue Value: 1 Titles: – TitleFull: PLoS ONE Type: main |
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