| Title: |
CD8+XCR1neg Dendritic Cells Express High Levels of Toll-Like Receptor 5 and a Unique Complement of Endocytic Receptors. |
| Authors: |
Wylie, Ben, Read, James, Buzzai, Anthony C., Wagner, Teagan, Troy, Niamh, Syn, Genevieve, Stone, Shane R., Foley, Bree, Bosco, Anthony, Cruickshank, Mark N., Waithman, Jason |
| Source: |
Frontiers in Immunology; 1/16/2019, pN.PAG-N.PAG, 16p |
| Subject Terms: |
TUMORS, DENDRITIC cells, LYMPHOID tissue, LABORATORY animals, PATHOGENIC microorganisms |
| Abstract: |
Conventional dendritic cells (cDC) resident in the lymphoid organs of mice have been classically divided into CD8+ and CD8neg subsets. It is well-established that CD8+ dendritic cells (DCs) and their migratory counterparts in the periphery comprise the cross-presenting cDC1 subset. In contrast, CD8neg DCs are grouped together in the heterogeneous cDC2 subset. CD8neg DCs are relatively poor cross-presenters and drive more prominent CD4+ T cell responses against exogenous antigens. The discovery of the X-C motif chemokine receptor 1 (XCR1) as a specific marker of cross-presenting DCs, has led to the identification of a divergent subset of CD8+ DCs that lacks the ability to cross-present. Here, we report that these poorly characterized CD8+XCR1neg DCs have a gene expression profile that is consistent with both plasmacytoid DCs (pDCs) and cDC2. Our data demonstrate that CD8+XCR1neg DCs possess a unique pattern of endocytic receptors and a restricted toll-like receptor (TLR) profile that is particularly enriched for TLR5, giving them a unique position within the DC immunosurveillance network. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
