Bibliographic Details
| Title: |
Occupational exposure to flour dust and the risk of head and neck cancer. |
| Authors: |
Carton, Matthieu, Menvielle, Gwenn, Cyr, Diane, Sanchez, Marie, Pilorget, Corinne, Guizard, Anne‐Valérie, Stücker, Isabelle, Luce, Danièle, for the Icare Study Group |
| Source: |
American Journal of Industrial Medicine; Oct2018, Vol. 61 Issue 10, p869-873, 5p |
| Subject Terms: |
HEAD & neck cancer, SQUAMOUS cell carcinoma, OCCUPATIONAL hazards, ALCOHOL drinking, LOGISTIC regression analysis |
| Abstract: |
Background: To investigate the association between head and neck squamous cell cancer (HNSCC) risk and occupational exposure to flour dust in women and men, using data from ICARE, a French population‐based case‐control study. Methods: The analysis included 2053 cases of HNSCC and 3507 controls. Lifelong occupational history was collected. A job‐exposure matrix was used to assess exposure to flour dust. Odds‐ratios (ORs) and 95% confidence intervals (CI), adjusted for smoking, alcohol drinking, and asbestos exposure, were estimated with logistic regression models. Results: Ever exposure to flour dust was associated with elevated ORs in women (OR = 2.15, 95%CI: 1.01 4.55) and in men (OR = 1.55, 95%CI: 1.11 2.17). In women, the risk increased with the probability, the duration, and the cumulative level of exposure. No dose‐response relationships were observed in men. Conclusions: Although the results were less conclusive in men than in women, overall, these findings provide some support to the hypothesis of a role of flour dust in the occurrence of HNSCC. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
