The P2Y12 Receptor Antagonist Ticagrelor Reduces Lysosomal pH and Autofluorescence in Retinal Pigmented Epithelial Cells From the ABCA4-/- Mouse Model of Retinal.
| Title: | The P2Y |
|---|---|
| Authors: | Lu, Wennan, Gómez, Néstor M., Lim, Jason C., Guha, Sonia, O’Brien-Jenkins, Ann, Coffey, Erin E., Campagno, Keith E., McCaughey, Stuart A., Laties, Alan M., Carlsson, Leif G., Mitchell, Claire H. |
| Source: | Frontiers in Pharmacology; 4/19/2018, p1-N.PAG, 10p |
| Subject Terms: | PLATELET aggregation inhibitors, RHODOPSIN, BIOFLUORESCENCE, THERAPEUTICS |
| Abstract: | The accumulation of partially degraded lipid waste in lysosomal-related organelles may contribute to pathology in many aging diseases. The presence of these lipofuscin granules is particularly evident in the autofluorescent lysosome-associated organelles of the retinal pigmented epithelial (RPE) cells, and may be related to early stages of age-related macular degeneration. While lysosomal enzymes degrade material optimally at acidic pH levels, lysosomal pH is elevated in RPE cells from the ABCA4-/- mouse model of Stargardt's disease, an early onset retinal degeneration. Lowering lysosomal pH through cAMP-dependent pathways decreases accumulation of autofluorescent material in RPE cells in vitro, but identification of an appropriate receptor is crucial for manipulating this pathway in vivo. As the P2Y |
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| Database: | Complementary Index |
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