Bibliographic Details
| Title: |
Rapid synthesis of carbonucleoside phophonate analogues as potential antiviral agents via a hydrophosphonylation reaction of ethynyl carbocyclic precursors. |
| Authors: |
Sidi Mohamed, Bemba, Périgaud, Christian, Peyrottes, Suzanne, Uttaro, Jean-Pierre, Mathé, Christophe |
| Source: |
New Journal of Chemistry; 1/15/2018, Vol. 42 Issue 2, p974-979, 6p |
| Subject Terms: |
ANTIVIRAL agents, CARBOCYCLIC compounds, CHEMICAL precursors |
| Abstract: |
A racemic synthesis of new carbocyclic nucleoside ethyl or vinylphosphonate analogues bearing purine bases (adenine and guanine) was accomplished using racemic (+/−)-4-O-protected-2-cyclopentanone. All compounds were prepared using a hydrophosphonylation reaction of ethynyl carbocyclic precursors followed by a Mitsunobu coupling reaction between the heterocyclic bases. After deprotection, the compounds were evaluated for their activity against a large number of viruses. However, none of them showed significant antiviral activity or cytotoxicity. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
