Bibliographic Details
| Title: |
Cytoplasmic c-Fos induced by the YXXQ-derived STAT3 signal requires the co-operative MEK/ERK signal for its nuclear translocation. |
| Authors: |
Higashi, Natsuko, Kunimoto, Hiroyuki, Shuhei Kaneko, Hiroyuki, Takanori Sasaki, Hiroyuki, Masamitsu Ishii, Hirotada Kojima, Hiroyuki, Koichi Nakajima, Hiroyuki |
| Source: |
Genes to Cells; Mar2004, Vol. 9 Issue 3, p233-242, 10p |
| Subject Terms: |
CELLULAR signal transduction, CYTOKINES, GENES, CYTOPLASM, CELL nuclei, CELL proliferation |
| Abstract: |
A STAT3 (signal transducer and activator of transcription 3)- and a MEK/Erk-mediated signal can be activated by cytokines, including IL-6 (interleukin-6), PDGF, and EGF. Recently, STAT3 and an ERK-signal were shown to co-operatively activate the c-fos gene. Activation of a truncated form of the IL-6 receptor subunit, gp130, that had only one YXXQ motif, induced both c-Fos and JunB in NIH3T3 cells through STAT3 without an apparent increase in the AP-1 (activator protein-1) activity. In contrast, concomitant stimulation of the STAT3 signal and a MEK/Erk-signal markedly increased AP-1 activity with enhanced c-Fos expression. Surprisingly, the c-Fos induced by the YXXQ-signal alone was localized to the cytoplasm, from which it translocated into the nucleus following TPA (12-O-tetradecanoyl-phorbol 13-acetate) treatment in a MEK/Erk-dependent manner. c-Fos that was expressed from a constitutive promoter localized to the nucleus and did not move into the cytoplasm in response to the YXXQ-signal. Rather, the YXXQ-signal was required during c-Fos production for it to be retained in the cytoplasm. Thus, the YXXQ-signal induces c-Fos expression through STAT3 and anchors the new c-Fos in the cytoplasm. In addition, the YXXQ-signal and an Erk signal co-operatively cause c-Fos activation in the nucleus. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
