Bibliographic Details
| Title: |
Successful oral desensitization with crizotinib after crizotinib-induced hepatitis in an anaplastic lymphoma kinase-rearranged non-small-cell lung cancer patient: A case report. |
| Authors: |
YUTO YASUDA, YASUYO NISHIKAWA, YUICHI SAKAMORI, MAKOTO TERAO, KENTARO HASHIMOTO, TOMOKO FUNAZO, TAKASHI NOMIZO, TAKAHIRO TSUJI, HIRONORI YOSHIDA, HIROKI NAGAI, HIROAKI OZASA, TOYOHIRO HIRAI, YOUNG HAK KIM |
| Source: |
Molecular & Clinical Oncology; 2017, Vol. 7 Issue 2, p295-297, 3p |
| Subject Terms: |
DESENSITIZATION (Psychotherapy), ANAPLASTIC lymphoma kinase, CRIZOTINIB |
| Abstract: |
Crizotinib is one of the molecularly-targeted agents targeted against anaplastic lymphoma kinase (ALK)-rearranged non-small-cell lung cancer (NSCLC). Although its effects appear to be promising, crizotinib may cause adverse effects in patients with ALK-rearranged NSCLC. Hepatic laboratory abnormalities are frequently observed with crizotinib and treatment discontinuation is occasionally required. We herein report the case of a 51-year-old woman diagnosed with relapsed ALK-rearranged NSCLC, who received crizotinib as second-line systemic chemotherapy. After 17 days of crizotinib therapy, the patient developed grade >3 hepatotoxicity. Treatment discontinuation improved the laboratory abnormalities and fifth-line oral desensitization with crizotinib achieved successful response without hepatotoxicity. Therefore, oral desensitization with crizotinib may be a viable option following crizotinib-induced hepatitis. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
