| Title: |
Pharmacological targeting of kinases MST1 and MST2 augments tissue repair and regeneration. |
| Authors: |
Fuqin Fan, Zhixiang He, Lu-Lu Kong, Qinghua Chen, Quan Yuan, Shihao Zhang, Jinjin Ye, Hao Liu, Xiufeng Sun, Jing Geng, Lunzhi Yuan, Lixin Hong, Chen Xiao, Weiji Zhang, Xihuan Sun, Yunzhan Li, Ping Wang, Lihong Huang, Xinrui Wu, Zhiliang Ji |
| Source: |
Science Translational Medicine; 8/17/2016, Vol. 8 Issue 352, p1-14, 14p, 7 Graphs |
| Subject Terms: |
PROTEIN kinases, REGENERATIVE medicine, TISSUE engineering, PHARMACEUTICAL research, ENZYME-linked immunosorbent assay |
| Abstract: |
The article discusses research which focused on the pharmacological modulation of MST1 and MST2 protein kinases for possible application in tissue regeneration and repair medicine. Topics explored include the use of an enzyme-linked immunosorbent assay (ELISA) in the discovery of the Hippo pathway inhibitor XMU-MP-1, the role of XMU-MP-1 in MST1 and MST2 kinase activities, and the cocrystallization of XMU-MP-1 to determine its structure. |
| Database: |
Complementary Index |
