| Title: |
Bioactive compounds isolated from garden snails. |
| Authors: |
Dolashka, Pavlina, Dolashki, Aleksander, Velkova, Lyudmila, Stevanovic, Stefan, Molin, Laura, Traldi, Pietro, Velikova, Radostina, Voelter, Wolfgang |
| Source: |
Journal of BioScience & Biotechnology; 2015 SpecialEdition, p147-155, 9p |
| Subject Terms: |
BIOACTIVE compounds, SNAILS, ANTINEOPLASTIC agents, PHYSIOLOGY |
| Abstract: |
The recent appearance of a growing number of resistant to conventional antibiotics, has become a serious medical problem. To overcome this resistance, the development of new compounds is encouraged. Hemolymph and mucus of Helix lucorum and Helix aspersa garden snails and Rapana venosa marine snail are a complex mixture of biochemically and pharmacologically active components. Glycoprotein 'hemocyanin' and antimicrobial peptides from the hemolymph and mucus are important components of the innate immunity. Some isoforms and peptides serve as effector molecules of the defense system, providing an efficient initial effect against infectious pathogens. The in vitro antitumor activity of Helix and Rapana hemocyanins and their isoforms with different oligosaccharide structures was established on the bladder carcinoma permanent cell lines T-24. This is probably due to the specific oligosaccharide structures of hemocyanins which are exposed on the surface of the molecule. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
