Bibliographic Details
| Title: |
AGXT2L1 is down-regulated in heptocellular carcinoma and associated with abnormal lipogenesis. |
| Authors: |
Qianshan Ding, Jian Kang, Jinfen Dai, Meng Tang, Qi Wang, Haotian Zhang, Wenyi Guo, Rongze Sun, Honggang Yu |
| Source: |
Journal of Clinical Pathology; Mar2016, Vol. 69 Issue 3, p215-220, 6p, 1 Chart, 4 Graphs |
| Subject Terms: |
ALANINE aminotransferase, LIVER cancer, IMMUNOHISTOCHEMISTRY, KAPLAN-Meier estimator, SMALL interfering RNA, GENE expression |
| Abstract: |
Aims To clarify the clinical implications and functional role of the alanine-glyoxylate aminotransferase 2-like 1 (AGXT2L1) gene in hepatocellular carcinoma (HCC). Methods and results We confirmed that AGXT2L1 was down-regulated in liver cancer samples by immunohistochemical (IHC) staining. We also demonstrated that this down-regulation was associated with several clinicopathological features such as alpha fetoprotein (AFP) serum level and T stage. Furthermore, we showed with Kaplan-Meier analysis that expression of AGXT2L1 in tumour samples was significantly correlated with patient prognosis. The bioinformatic tool indicated that AGXT2L1 plays a role in the lipid metabolic process of HCC tissue, while siRNA silenced the expression of AGXT2L1 in HCC 97H and LM3 cells, confirming that down-regulation of AGXT2L1 promotes the lipogenesis of cancer cells. Conclusions For the first time, we have shown that AGXT2L1 is down-regulated in HCC and its low expression indicates a poor prognosis. Our findings also demonstrated that AGXT2L1 is a crucial gene in the abnormal lipogenesis of HCC tissue. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
