Bibliographic Details
| Title: |
A native interactor scaffolds and stabilizes toxic ATAXIN-1 oligomers in SCA1. |
| Authors: |
Lasagna-Reeves, Cristian A., Rousseaux, Maxime W. C., Guerrero Muñoz, Marcos J., Jeehye Park, Jafar-Nejad, Paymaan, Richman, Ronald, Nan Lu, Sengupta, Urmi, Litvinchuk, Alexandra, Orr, Harry T., Kayed, Rakez, Zoghbi, Huda Y. |
| Source: |
eLife; May2015, p1-21, 21p |
| Subject Terms: |
POLYGLUTAMINE, SPINOCEREBELLAR ataxia, OLIGOMERS |
| Abstract: |
The article presents a study investigating whether polyglutamine-expanded ATAXIN-1, the protein that underlies spinocerebellar ataxia type 1, forms toxic oligomers and, if so, what underlies their toxicity. |
| Database: |
Complementary Index |
