| Title: |
Red cell and platelet transfusions in neonates: a population-based study. |
| Authors: |
Pak Cheung Ng, Terence Ping Yuen Ma, Hugh Simon Lam |
| Source: |
Archives of Disease in Childhood -- Fetal & Neonatal Edition; Sep2015, Vol. 100 Issue 5, pF411-F415, 5p, 2 Charts, 1 Graph |
| Subject Terms: |
NEONATAL necrotizing enterocolitis, SEPTICEMIA in children, DIAGNOSIS of neonatal diseases, BIOMARKERS, NEONATAL diseases, HEALTH outcome assessment, PROGNOSIS, DIAGNOSIS, THERAPEUTICS |
| Abstract: |
Objectives: This study aimed to describe the use of red cells, platelets and exchange transfusions among all neonates in a population cohort, to examine trends in transfusion over time and to determine transfusion rates in at-risk neonates. Design: Linked population-based birth and hospital data from New South Wales (NSW), Australia, were used to determine rates of blood product transfusion in the first 28 days of life. The study included all live births ≥23 weeks' gestation in NSW between 2001 and 2011. Results: Between 2001 and 2011, 5326 of 989 491 live born neonates received a red cell, platelet or exchange transfusion (5.4/1000 births). Transfusion rates were 4.8 per 1000 for red cells, 1.3 per 1000 for platelets and 0.3 per 1000 for exchange transfusion. Overall transfusion rate remained constant from 2001 to 2011 (p=0.27). Among transfused neonates, 60% were <32 weeks' gestation (n=3210, 331/1000 births), 40% were =32 weeks' gestation (n= 2116, 2/1000 births) and 7% received transfusions in a hospital without a neonatal intensive care unit (NICU). Factors other than prematurity associated with higher transfusion rates were prior in utero transfusion (631/1000), congenital anomaly requiring surgery (440/1000) and haemolytic disorder (106/1000). Conclusions: In this population-based study, preterm neonates had a higher rate of transfusion than term neonates; however, 40% of those who received a transfusion were born =32 weeks' gestation and 7% were transfused in hospitals without an NICU. These findings need to be considered by transfusion services and personnel developing neonatal transfusion guidelines. [ABSTRACT FROM AUTHOR] |
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| Database: |
Complementary Index |
