Bibliographic Details
| Title: |
Saccharomyces cerevisiae-derived vesicles loaded with dextromethorphan as a candidate for the management of neuroinflammation related to Alzheimer’s disease. |
| Authors: |
Valizadeh, Parastoo1,2 (AUTHOR), Mozafari, Negin2 (AUTHOR), Ashrafi, Hajar2 (AUTHOR), Heidari, Reza3 (AUTHOR), Azarpira, Negar4 (AUTHOR), Azadi, Amir2,3 (AUTHOR) aazadi@sums.ac.ir |
| Source: |
Pharmaceutical Development & Technology. Feb2025, p1-9. 9p. 6 Illustrations. |
| Subject Terms: |
Central nervous system injuries, Targeted drug delivery, Drug delivery systems, Particle size distribution, Encephalitis |
| Abstract: |
AbstractAlzheimer’s disease (AD) is a neurodegenerative disease that is associated with neuroinflammation. Dextromethorphan (DXM) exerts neuroprotective effects in many central nervous system injuries and neurodegenerative diseases. The cell wall of Saccharomyces cerevisiae is a cell-based drug delivery system that can be a suitable candidate for targeted drug delivery to the site of inflammation. In this study, nanoparticles (NPs) were prepared from Saccharomyces cerevisiae cell walls, coated with polysorbate-80, and loaded with DXM. NPs had favorable hemolytic behavior with a particle size distribution of 187.25 ± 73.37 nm and a zeta potential of +4.3 mV. Pathological examination in a mouse model of neuroinflammation showed that NPs had the ability to reduce brain inflammation and the adverse effects of DXM. [ABSTRACT FROM AUTHOR] |
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| Database: |
Business Source Complete |
