Bibliographic Details
| Title: |
Tubeimoside-1 Inhibits Pancreatic Tumor Cell Growth and Enhances Tumor Cell Sensitivity to Gemcitabine. |
| Authors: |
Jun Wang1, Shi Wang1, Xiaopeng Fan1, Hailin Ye1 yehailin4030501@163.com |
| Source: |
Current Topics in Nutraceutical Research. Aug2024, Vol. 22 Issue 3, p861-867. 7p. |
| Subject Terms: |
*Research funding, Triterpenes, Drug resistance in cancer cells, Chalones, Antineoplastic agents, Apoptosis, Biological products, Tumor markers, Treatment effectiveness, Pancreatic tumors, Cell lines, Cancer chemotherapy, Plant extracts, Gene expression, Gemcitabine, Glycosides, Medicinal plants, mTOR inhibitors, Rapamycin, Pharmacodynamics |
| Abstract: |
Pancreatic tumor is one of the deadliest malignancies and the effective rate of chemotherapy for pancreatic tumor is still low. It is important to identify effective treatments and drugs that are sensitive to chemotherapy drugs. Tubeimoside-1 is a natural compound is traditionally used to treat snake venom and inflammation, and it has anti-tumor activities in multiple tumors. However, the role and mechanism of Tubeimoside-1 in pancreatic tumor has been unclear. Herein, we investigated the role of TBMS1 in the chemotherapy resistance of pancreatic tumor. We revealed that TBMS1 restrained the growth of pancreatic tumor cells. In addition, TBMS1 contributed to the apoptosis of pancreatic tumor cells. Further, tubeimoside-1 enhanced the sensitivity of pancreatic tumor gemcitabine resistant cells to gemcitabine. Mechanically, tubeimoside-1 inhibited the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin axis in pancreatic tumor cells. In summary, tubeimoside-1 inhibited the phosphatidylinositol-3-kinase/protein kinase B/mammalian target of rapamycin axis, thereby restraining pancreatic tumor cell growth and gemcitabine resistance. [ABSTRACT FROM AUTHOR] |
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| Database: |
Business Source Complete |
