Bibliographic Details
| Title: |
In vivo antioxidants, chemical characterization and biochemical and medicinal potential of Murraya koenigii in cisplatin-induced nephrotoxicity. |
| Authors: |
Nazeer, Hafiza Yusra1 (AUTHOR), Iqbal, Muhammad Omer2,3 (AUTHOR), Mumtaz, Asma4,5 (AUTHOR), Ahmed, Muhammad Masood6,7 (AUTHOR), Riaz, Romana4 (AUTHOR), Rasool, Muhammad Fawad8 (AUTHOR) |
| Source: |
Drug Development & Industrial Pharmacy. Oct2022, Vol. 48 Issue 10, p566-574. 9p. |
| Subject Terms: |
Curry leaf tree, Nephrotoxicology, Phytochemicals, Tannins, Phenols, Laboratory rats |
| Geographic Terms: |
Asia, Africa |
| Abstract: |
Murraya koenigii (Mk) is an old plant with a significant therapeutic value throughout Africa, Asia, and Latin America. The excessive use of cisplatin (Cis> 50 mg/m2) is associated with nephrotoxicity, ototoxicity, gastrotoxicity, myelosuppression, and allergic reactions. Remedial measures are needed for the protection of nephrotoxicity against cisplatin. Thus, we have investigated Mk leaf extract's nephroprotective effects to prevent cisplatin-induced nephrotoxicity in Wistar albino rats. The presence of polyphenols, phenolic compounds, tannins, and saponins was revealed during phytochemical investigation, and antioxidant activity was recorded. There were no toxicological symptoms in the treated rats, and no anatomical, physiological, or histological abnormalities were found compared to the control rats. The results of correcting cisplatin-induced nephrotoxicity revealed that the extract has a significant ability to treat kidney damage, with most parameters returning to normal after only three weeks of therapy. It was concluded that co-administered cisplatin with Mk leaves extract showed exceptional nephroprotective effects at a 400 mg/kg dose ratein Cis-induced nephrotoxicity. [ABSTRACT FROM AUTHOR] |
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| Database: |
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