Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography.

Bibliographic Details
Title:	Binding‐Site Purification of Actives (B‐SPA) Enables Efficient Large‐Scale Progression of Fragment Hits by Combining Multi‐Step Array Synthesis With HT Crystallography.
Authors:	Grosjean, Harold^1,2, Aimon, Anthony^1,3, Hassell‐Hart, Storm⁴, Thompson, Warren^1,3, Koekemoer, Lizbé^5,6, Bennett, James^5,6, Bradley, Anthony⁶, Anderson, Cameron², Wild, Conor^1,6, Bradshaw, William J.⁵, FitzGerald, Edward A.⁷, Krojer, Tobias⁶, Fedorov, Oleg⁶, Biggin, Philip C.², Spencer, John^4,8, j.spencer@sussex.ac.uk, von Delft, Frank^1,3,5,6,9, frank.vondelft@cmd.ox.ac.uk
Source:	Angewandte Chemie International Edition; 4/11/2025, Vol. 64 Issue 16, p1-15, 15p
Database:	Applied Science & Technology Source

More Details
ISSN:	14337851
DOI:	10.1002/anie.202424373
Published in:	Angewandte Chemie International Edition
Language:	English