Bibliographic Details
| Title: |
Generic--equivalent drugs use in internal and general medicine patients: distrust, confusion, lack of certainties or knowledge? Part 1. Pharmacological issues. |
| Authors: |
Nardi, Roberto1 nardidoc48@gmail.com, Masina, Marco2, Cioni, Giorgio3, Leandri, Paolo1, Zuccheri, Paola4 |
| Source: |
Italian Journal of Medicine. 2014, Vol. 8 Issue 2, p80-87. 8p. 3 Charts, 2 Graphs. |
| Subject Terms: |
*GENERIC drugs, *INTERNAL medicine, *GUIDELINES, *MEDICAL care costs, *THERAPEUTIC equivalency in drugs |
| Geographic Terms: |
ITALY |
| Abstract: |
Despite compelling evidence and guidelines, in Italy, generic/equivalent drugs are still underused. The failure to adopt existing generic drugs may result into a missed opportunity to further reduce healthcare costs. Equivalent drugs are approved based on data deriving from bioequivalence studies. In the first part of the article, the concepts of generic/equivalent drugs are defined, emphasizing the differences between pharmaceutical equivalence, therapeutic equivalence, bioequivalence and bioavailability. A summary of the methods adopted to define bioequivalence (pharmacokinetic studies; pharmacodynamic studies; comparative clinical trials; in vitro studies) is also included. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Complete |
