Bibliographic Details
| Title: |
Foxp3 programs the development and function of CD4+CD25+ regulatory T cells. |
| Authors: |
Fontenot, Jason D., Gavin, Marc A., Rudensky, Alexander Y. |
| Source: |
Nature Immunology. Apr2003, Vol. 4 Issue 4, p330. 7p. |
| Subject Terms: |
*T cells, *AUTOIMMUNITY, *TRANSCRIPTION factors |
| Abstract: |
CD4[SUP+]CD25[SUP+] regulatory T cells are essential for the active suppression of autoimmunity. Here we report that the forkhead transcription factor Foxp3 is specifically expressed in CD4[SUP+]CD25[SUP+] regulatory T cells and is required for their development. The lethal autoimmune syndrome observed in Foxp3-mutant scurfy mice and Foxp3-null mice results from a CD4[SUP+]CD25[SUP+] regulatory T cell deficiency and not from a cell-intrinsic defect of CD4[SUP+]CD25-T cells. CD4[SUP+]CD25[SUP+] regulatory T cells rescue disease development and preferentially expand when transferred into neonatal Foxp3deficient mice. Furthermore, ectopic expression of Foxp3 confers suppressor function on peripheral CD4[SUP+]CD25-T cells. Thus, Foxp3 is a critical regulator of CD4[SUP+]CD25[SUP+] regulatory T cell development and function. [ABSTRACT FROM AUTHOR] |
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| Database: |
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