Bibliographic Details
| Title: |
Preliminary results of radiotherapy for primary intraocular non-Hodgkin lymphoma. |
| Authors: |
Mikami, Ryuji1 (AUTHOR) mikami-r@tokyo-med.ac.jp, Nakayama, Hidetsugu1 (AUTHOR), Goto, Hiroshi2 (AUTHOR), Kimura, Keisuke2 (AUTHOR), Usui, Yoshihiko2 (AUTHOR), Nogi, Sachika1 (AUTHOR), Tajima, Yu1 (AUTHOR), Okubo, Mitsuru1 (AUTHOR), Kanesaka, Naoto1 (AUTHOR), Sugahara, Shinji1 (AUTHOR), Tokuuye, Koichi1 (AUTHOR) |
| Source: |
Leukemia & Lymphoma. Oct2013, Vol. 54 Issue 10, p2181-2184. 4p. |
| Subject Terms: |
*HEALTH outcome assessment, *LYMPHOMA treatment, *RADIOTHERAPY, *MEDICAL radiology, *CANCER radiotherapy research |
| Abstract: |
This study aimed to retrospectively evaluate the efficacy of radiotherapy for primary intraocular non-Hodgkin lymphoma (PIOL). Between May 1998 and October 2010, 22 immunocompetent patients (four men, 18 women; median age 70 years, range 53-79 years) were diagnosed with PIOL. Magnetic resonance imaging showed no intracranial involvement in any patient. Patients received radiotherapy at a median total dose of 30 Gy (range 30-40 Gy). Three-year overall survival, progression-free survival and local control rates were 89% (95% confidence interval [CI]: 75, 103), 49% (95% CI: 24, 73) and 95% (95% CI: 86, 105) over a median of 36 months of observation, respectively. Twelve patients (55%) had intracranial relapse at a median of 28 months after initiation of radiotherapy. Visual acuity improved or was stable in 81% of treated eyes. The only grade ≥ 3 toxicity was cataract formation (five patients). Radiotherapy without chemotherapy for PIOL achieved high local control rates with acceptable toxicities. [ABSTRACT FROM AUTHOR] |
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