| Title: |
SNPs of bovine HGF gene and their association with growth traits in Nanyang cattle. |
| Authors: |
Hanfang Cai1, Xianyong Lan1, Aimin Li1, Yang Zhou1, Jiajie Sun1, Chuzhao Lei1, Chunlei Zhang2, Hong Chen1 chenhong1212@263.net |
| Source: |
Research in Veterinary Science. 2013, Vol. 95 Issue 2, p483-488. 6p. |
| Subject Terms: |
*SINGLE nucleotide polymorphisms, *HEPATOCYTE growth factor, *CATTLE physiology, *MISSENSE mutation, *NUCLEOTIDE sequence, *RESTRICTION fragment length polymorphisms, *POLYMERASE chain reaction |
| Abstract: |
Hepatocyte growth factor (HGF) is one of the multifunctional cell factors that regulates cellular proliferation, motility and morphogenesis in mammalians. And its medical research has deep significance. In this paper, polymorphisms of HGF gene were investigated in 1433 health and irrelated Chinese cattle by PCRRFLP and DNA sequencing approach. Ten novel Single nucleotide polymorphisms (SNPs) were identified, which included one missense mutation, g.72801G>A in the coding region, and the others in the intron. Association analysis between four of them, g.288T>C, g.72801G>A, g.77172G>T, and g.77408T>G, and growth traits in Nanyang, were performed. The results indicated that SNPs within bovine HGF gene were significantly associated with growth traits. Phylogenetic analysis showed that the genetic background of Caoyuan Red cattle was different from the others in the tested breeds. The findings will provide a background for application of bovine HGF gene in the selection program in Chinese cattle. [ABSTRACT FROM AUTHOR] |
|
Copyright of Research in Veterinary Science is the property of Elsevier B.V. and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
