Bibliographic Details
| Title: |
Fatigue in bronchiectasis. |
| Authors: |
Hester, K.L.M.1, Macfarlane, J.G.1, Tedd, H.1, Jary, H.1, McAlinden, P.1, Rostron, L.1, Small, T.1, Newton, J.L.1, De Soyza, A.1 |
| Source: |
QJM: An International Journal of Medicine. Mar2012, Vol. 105 Issue 3, p235-240. 6p. |
| Subject Terms: |
*BRONCHIECTASIS, *FATIGUE (Physiology), *CYSTIC fibrosis, *CLINICAL trials, *PSEUDOMONAS aeruginosa infections, *SPUTUM, *DYSPNEA |
| Abstract: |
Background: Fatigue is a complex, disabling symptom in non-CF bronchiectasis (nCF-Br). Fatigue can be formally measured using the validated fatigue impact scale (FIS). The relationship between fatigue and clinically important factors such as airflow obstruction, breathlessness or Pseudomonas aeruginosa infection in nCF-Br is unclear.Aim: To measure the correlation between FIS scores and markers of disease severity in nCF-Br.Design: A prospective cohort study.Methods: Patients attending a specialist service were studied. Lung function (FEV1% predicted), Medical Research Council dyspnoea score (MRCD), sputum culture results and FIS were recorded. Patients were categorized according to sputum culture into three subgroups: Pseudomonas ‘colonization’, ‘isolation’ and neither.Results: One hundred and seventeen consecutive patients were included. Average FEV1% predicted was 64% (SD ±28%). Twelve (10%) patients had Pseudomonas aeruginosa isolation; 47 (40%) patients had P. aeruginosa colonization. Fatigue levels were similar in patients with and without colonization (median 38 versus 32, P = 0.155). Significant fatigue (FIS > 40) was similar in all three Pseudomonas subgroups (P = 0.31, chi-square). Fatigue correlated with MRCD score (r = 0.57, P < 0.001) and FEV1% predicted (r = −0.30, P = 0.001). FEV1% predicted was lower in patients who had ever isolated or been colonized with P. aeruginosa (P ≤ 0.001).Conclusions: There are significant correlations between FIS score and MRCD score and FEV1% predicted in bronchiectasis. Pseudomonas aeruginosa infection appears to be associated with poorer lung function, and higher MRCD scores, yet there is no significant association between P. aeruginosa status and fatigue. [ABSTRACT FROM PUBLISHER] |
|
Copyright of QJM: An International Journal of Medicine is the property of Oxford University Press / USA and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
