Bibliographic Details
| Title: |
Antibody-Based Therapies inMultipleMyeloma. |
| Authors: |
Yu-Tzu Tai1 yu-tzutai@dfci.harvard.edu, Anderson, Kenneth C.1 |
| Source: |
Bone Marrow Research. 2011, p1-14. 14p. 1 Diagram, 1 Chart. |
| Subject Terms: |
*MULTIPLE myeloma, *MONOCLONAL antibodies, *CANCER cells, *IMMUNE response, *CLINICAL trials, PURE Food & Drug Act of 1906 |
| Geographic Terms: |
UNITED States |
| Abstract: |
The unmet need for improved multiple myeloma (MM) therapy has stimulated clinical development of monoclonal antibodies (mAbs) targeting either MM cells or cells of the bone marrow (BM) microenvironment. In contrast to small-molecule inhibitors, therapeutic mAbs present the potential to specifically target tumor cells and directly induce an immune response to lyse tumor cells. Unique immune-effector mechanisms are only triggered by therapeutic mAbs but not by small molecule targeting agents. Although therapeutic murine mAbs or chimeric mAbs can cause immunogenicity, the advancement of genetic recombination for humanizing rodent mAbs has allowed large-scale production and designation of mAbs with better affinities, efficient selection, decreasing immunogenicity, and improved effector functions. These advancements of antibody engineering technologies have largely overcome the critical obstacle of antibody immunogenicity and enabled the development and subsequent Food and Drug Administration (FDA) approval of therapeutic Abs for cancer and other diseases. [ABSTRACT FROM AUTHOR] |
|
Copyright of Bone Marrow Research is the property of Wiley-Blackwell and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
