Bibliographic Details
| Title: |
Evaluation of UGT1A1 and SULT1A1 polymorphisms with lipid levels in women with different hormonal status. |
| Authors: |
Smiderle, Lisiane1,2 (AUTHOR), Galvão, Ananda Cristine Santos1,2 (AUTHOR), Fontana, Crisciele2 (AUTHOR), Wender, MARIA Celeste Osório3 (AUTHOR), Agnes, Grasiela2 (AUTHOR), Giovenardi, Márcia1 (AUTHOR), Helena Hutz, Mara4 (AUTHOR), Almeida, Silvana1,2 (AUTHOR) silvana.almeida@pq.cnpq.br |
| Source: |
Gynecological Endocrinology. Jan2011, Vol. 27 Issue 1, p20-26. 7p. |
| Subject Terms: |
*ISOHORMONES, *GENETIC polymorphisms, *LIPIDS, *ENDOCRINE diseases, *GLUCURONOSYLTRANSFERASE, *SULFOTRANSFERASES, *CARDIOVASCULAR diseases, *PHARMACOGENOMICS |
| Abstract: |
Background. Estrogens influence many physiological processes including cardiovascular health. Polymorphisms in phase I and II estrogen metabolism enzymes are associated with lipid levels in women. Methods. A cross-sectional study was carried out with 269 postmenopausal women, 116 who received oral hormonal therapy (HT) (39-75 years) with estrogens or estrogens plus progestagen, 153 that did not receive any HT (38-85 years), and 155 premenopausal women (18-52 years). Polymorphisms in UGT1A1 (rs5839491) and SULT1A1 (rs1042028) were analysed by PCR-based methods. Adjusted lipid levels means were compared among genotypes by one-way analysis of variance, with corrections for multiple testing. Results. The UGT1A1*28 polymorphism was associated with total cholesterol (T-chol) ( p = 0.030; corrected p = 0.060) and low-density lipoprotein cholesterol (LDL-C) levels ( p = 0.011, corrected p = 0.022) in premenopausal women. The premenopausal and postmenopausal women, both carriers of SULT1A1*2/*2, had lower levels of T-chol and LDL-C means than carriers of the SULT1A1*1/*1 ( p = 0.004, corrected p = 0.008 and 0.009, corrected p = 0.018, respectively). Conclusion. The data showed the presence of an association between the UGT1A1*28/*28 and SULT1A1*2/*2 and T-chol and LDL-C levels in women with different hormonal status. No previous studies investigated the association of the polymorphisms examined in this study with lipoprotein levels in women separately by hormonal status. [ABSTRACT FROM AUTHOR] |
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