Bibliographic Details
| Title: |
Size distribution of embolic material produced at aortic cross-clamp manipulation. |
| Authors: |
Boivie, Patrik1 (AUTHOR), Hedberg, Magnus2 (AUTHOR) magnus.hedberg@vll.se, Engström, Karl Gunnar2 (AUTHOR) |
| Source: |
Scandinavian Cardiovascular Journal. Dec2010, Vol. 44 Issue 6, p367-372. 6p. 1 Diagram, 1 Chart, 2 Graphs. |
| Subject Terms: |
*ATHEROSCLEROSIS, *CARDIAC surgery, *PARTICLE size distribution, *PERFUSION, *THERAPEUTICS, *HEART diseases |
| Abstract: |
Objectives. The association between aortic atherosclerosis and neurological damage during cardiac surgery is well recognized. The purpose was here to analyze the size distribution of particles produced at cross-clamp manipulation of the ascending aorta. Design. A human cadaveric aortic perfusion model of retrograde design was applied (n=27). With this model, washout samples were collected from the pressurized ascending aorta during cross clamp manipulation. Before the experiment, the aorta was flushed to remove debris and with a baseline sample collected. The cross-clamp was opened to collect ten repeated aliquots with dislodged particles. Collected washout samples were evaluated by digital image analysis and microscopy. Results. Cross-clamping produced a significant output of particles, which was seen for size intervals of 1 mm and smaller (p=0.002 to p=0.022). In all size intervals the particle output correlated with the degree of overall aortic calcification (p=0.002 to p=0.025). The model generated substantially more small-size particles than large debris (p<0.010). Conclusions. Aortic clamping was here verified to dislodge aortic debris which correlated with the degree of observed calcification. Macroscopic particles were few. In contrast, cross-clamping produced substantial numbers of small-size particles. These findings emphasize microembolic risks associated with cross-clamping of atherosclerotic vessels. [ABSTRACT FROM AUTHOR] |
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