Bibliographic Details
| Title: |
Association of Linear Growth Impairment in Pediatric Crohn's Disease and a Known Height Locus: A Pilot Study. |
| Authors: |
Lee, Jessica J.1 Jessica.lee@childrens.harvard.edu, Essers, Jonah B.1,2, Kugathasan, Subra3, Escher, Johanna C.4, Lettre, Guillaume5, Butler, Johannah L.6, Stephens, Michael C.7, Ramoni, Marco F.8,9, Grand, Richard J.1,10, Hirschhorn, Joel2,6 |
| Source: |
Annals of Human Genetics. Nov2010, Vol. 74 Issue 6, p489-497. 9p. 3 Charts. |
| Subject Terms: |
*ETIOLOGY of diseases, *CROHN'S disease, *INFLAMMATORY bowel diseases, *GENETIC polymorphisms, *GENE frequency |
| Abstract: |
The etiology of growth impairment in Crohn's disease (CD) has been inadequately explained by nutritional, hormonal, and/or disease-related factors, suggesting that genetics may be an additional contributor. The aim of this cross-sectional study was to investigate genetic variants associated with linear growth in pediatric-onset CD. We genotyped 951 subjects (317 CD patient-parent trios) for 64 polymorphisms within 14 CD-susceptibility and 23 stature-associated loci. Patient height-for-age Z-score < −1.64 was used to dichotomize probands into growth-impaired and nongrowth-impaired groups. The transmission disequilibrium test (TDT) was used to study association to growth impairment. There was a significant association between growth impairment in CD (height-for-age Z-score < −1.64) and a stature-related polymorphism in the dymeclin gene DYM (rs8099594) (OR = 3.2, CI [1.57-6.51], p = 0.0007). In addition, there was nominal over-transmission of two CD-susceptibility alleles, 10q21.1 intergenic region (rs10761659) and ATG16L1 (rs10210302), in growth-impaired CD children (OR = 2.36, CI [1.26-4.41] p = 0.0056 and OR = 2.45, CI [1.22-4.95] p = 0.0094, respectively). Our data indicate that genetic influences due to stature-associated and possibly CD risk alleles may predispose CD patients to alterations in linear growth. This is the first report of a link between a stature-associated locus and growth impairment in CD. [ABSTRACT FROM AUTHOR] |
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