Bibliographic Details
| Title: |
Pneumocystis jirovecii infection: Cell wall (1→3)-β-D-glucan biology and diagnostic utility. |
| Authors: |
Finkelman, Malcolm A.1 (AUTHOR) |
| Source: |
Critical Reviews in Microbiology. Nov2010, Vol. 36 Issue 4, p271-281. 11p. 2 Diagrams, 1 Chart. |
| Subject Terms: |
*PNEUMOCYSTIS carinii pneumonia diagnosis, *PATHOLOGICAL physiology, *LIGANDS (Biochemistry), *SEROTHERAPY, *IMMUNOSUPPRESSION, *GENETICS |
| Abstract: |
Pneumocystis jirovecii has emerged as an important pulmonary pathogen. Historically associated with the immunocompromised, it is being increasingly observed in immunocompetent populations. (1→3)-β-D-glucan (BG) is a major component of the cyst cell wall and plays an important role in the inflammatory response to the organism. Inflammatory synergy by co-stimulation with BG and Toll-like receptor ligands has been demonstrated in vitro and may be a factor in the pathophysiology of Pneumocystis pneumonia. Detection of highly elevated serum concentrations of BG in the serum of patients has been shown to be highly sensitive for the presence of pulmonary P. jirovecii. [ABSTRACT FROM AUTHOR] |
|
Copyright of Critical Reviews in Microbiology is the property of Taylor & Francis Ltd and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.) |
| Database: |
Academic Search Complete |
|
Full text is not displayed to guests. |
Login for full access.
|
Full Text from Taylor & Francis