Bibliographic Details
| Title: |
Role of IL-13 in a model of Strongyloides venezuelensis infection in rats |
| Authors: |
Ferreira, Caroline M.1, Pereira, Ana T.M.2, Souza, Rafael S. de1, Coelho, Fernanda M.1, Poole, Stephen3, Teixeira, Mauro M.1, Negrão-Corrêa, Deborah2 denegrao@icb.ufmg.br |
| Source: |
Microbes & Infection. May2010, Vol. 12 Issue 5, p409-414. 6p. |
| Subject Terms: |
*INTERLEUKIN-13, *PNEUMONIA, *STRONGYLOIDIASIS, *AIRWAY (Anatomy), *AGRICULTURAL egg production, *LABORATORY rats |
| Abstract: |
Abstract: IL-13 is a cytokine known to play a role in several pulmonary diseases, including asthma and fibrosis. The role of IL-13 in the context of pulmonary changes induced by helminth infection is unclear. Rats experimentally infected with Strongyloides venezuelensis and treated with anti-IL-13 neutralizing antibody were used to evaluate the role of IL-13 on functional and inflammatory changes of host lungs, and on parasite control. S. venezuelensis-induced airway hyperreactivity was IL-13-independent, but IL-13 played an essential role in driving airway mucus production and eosinophil infiltration. IL-13 was important for the control of egg production but not establishment in the intestine. [Copyright &y& Elsevier] |
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| Database: |
Academic Search Complete |
