Bibliographic Details
| Title: |
Evaluation of estrogen receptor alpha, estrogen receptor beta, progesterone receptor, and cKIT expression in desmoids tumors and their role in determining treatment options. |
| Authors: |
Santos, Gabriel A. C.1, Cunha, Isabela W.2, Rocha, Rafael M.2 rafael.malagoli@gmail.com, Mello, Celso A. L.3, Guimarães, Gustavo C.1, Fregnani, José H.1, Lopes, Ademar1 |
| Source: |
BioScience Trends. Feb2010, Vol. 4 Issue 1, p25-30. 6p. 4 Charts, 4 Graphs. |
| Subject Terms: |
*ESTROGEN receptors, *PROGESTERONE receptors, *TUMOR treatment, *IMMUNOHISTOCHEMISTRY, *TAMOXIFEN, *HORMONE therapy, *DRUG therapy, *CELL proliferation, *RADIOTHERAPY |
| Abstract: |
The present study evaluates the protein expression of estrogen receptor alpha (ERα), estrogen receptor beta (ERβ), progesterone receptor (PR) and cKIT in a wide number of desmoids tumors and their role in determining treatment options. Fifty-nine cases classified as muscle aponeurotic fibromatosis were selected. Samples were grouped bytumor location in: head and neck, extremity and abdominal/trunk; type of resection of the primary tumor (complete resection with adequate margins, marginal resection andresection with inadequate margins); type of treatment (exclusive surgery, surgery followed by radiation therapy and surgery followed by tamoxifen or cyclooxygenase inhibitor). A tissue microarray (TMA) was built and the immunohistochemical reactions were performed against ERα, ERβ, PR, and c-kit. All cases were negative for ERα, PR and c-KIT. 53/59 cases were positive for ERβ. No significant difference was observed among clinical variables and the ERβ status. The estimated 5 and 10 year local recurrence free survival (LRFS) for the patients with complete or marginal resection was 75% and 75%, respectively. Tumor location (p = 0.006) and type of resection (p = 0.001) were predictive of local relapse in the univariate analysis. All patients treated with post-operative tamoxifen were LRFS (p = 0.035). Head and neck and extremities lesions showed higher recurrence rates compared to abdominal/trunk lesions. Marginal resection was associated with local recurrence. In conclusion, although this is a retrospective study, the results presented can contribute to better understanding of the mechanisms under desmoid tumor development and can propose tamoxifen as a therapeutic option to be tested in prospective trials. [ABSTRACT FROM AUTHOR] |
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| Database: |
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