| Title: |
A vaccine candidate against the human papillomavirus: an alternative to treat cervico-uterine tumors. |
| Authors: |
del Carmen Torréns, Isis1 isis.torrens@cigb.edu.cu, Mendoza, Osmany1, Reyes, Osvaldo1, Batte, Aileen1, Granadillo, Milaid1, Fernández, Luis E.2, Guillén, Gerardo1 |
| Source: |
Biotecnologia Aplicada. abr-jun2008, Vol. 25 Issue 2, p180-182. 3p. 1 Chart, 2 Graphs. |
| Subject Terms: |
*PAPILLOMAVIRUSES, *CERVICAL cancer treatment, *VIRAL antigens, *CANCER vaccines, *IMMUNOTHERAPY, *SPONTANEOUS cancer regression, *RESEARCH methodology, *LABORATORY mice, *THERAPEUTICS |
| Abstract: |
In this study, we obtained a vaccine against tumors generated by the human papillomavirus type 16 (HPV16), a current and highly relevant issue in the field of cancer immunotherapy. In contrast to some vaccines currently being tested in clinical trials against the HPV , of which none of them have been approved, the novelty of this result is the design of an original vaccine, based on a synthetic peptide spanning the minimal sequence of a cytotoxic T lymphocyte (CTL) epitope from the HPV tumor antigen E7, which was adjuvanted with VSSP (Very Small Size Proteoliposomes, Center for Molecular Immunology, Cuba). Its proof-of-concept in the murine HPV16 tumor model demonstrated the induction of CD8+ T cells specific against the E7 epitope in mice treated with this vaccine candidate, as well as tumor regression and a significant increase in survival. This is the first report describing the induction of tumor regression by therapeutic immunization with a minimal CTL epitope and VSSP , and the first example of cancer immunotherapy by combining VSSP with a viral antigen. These results have been patented, presented in several international scientific conferences and published in "Vaccine" (Torréns I, Mendoza O, Batte A, Reyes O, Fernández LE, Mesa C, et al. Immunotherapy with CTL peptide and VSSP eradicated established human papillomavirus (HPV) type 16 E7-expressing tumors. Vaccine 2005;23:5768-74). [ABSTRACT FROM AUTHOR] |
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