Bibliographic Details
| Title: |
Cytokine gene polymorphisms and the risk of adenocarcinoma of the stomach in the European prospective investigation into cancer and nutrition (EPIC-EURGAST). |
| Authors: |
J. B. A. Crusius, F. Canzian, G. Capellá, A. S. Peña, G. Pera, N. Sala, A. Agudo, F. Rico, G. Del Giudice, D. Palli, M. Plebani, H. Boeing, H. B. Bueno-de-Mesquita, F. Carneiro, V. Pala, V. E. Save, P. Vineis, R. Tumino, S. Panico, G. Berglund |
| Source: |
Annals of Oncology. Nov2008, Vol. 19 Issue 11, p1894-1894. 1p. |
| Subject Terms: |
*STOMACH cancer risk factors, *ADENOCARCINOMA, *GENETIC polymorphisms, *GASTRIC mucosa, *HELICOBACTER pylori, *PHENOTYPES, *CANCER patients, *GENETICS, *CANCER |
| Abstract: |
Background: The relative contribution to gastric cancer (GC) risk of variants in genes that determine the inflammatory response remains mostly unknown and results from genotyping studies are inconsistent. Patients and methods: A nested caseâcontrol study within the prospective European Prospective Investigation into Cancer and Nutrition cohort was carried out, including 248 gastric adenocarcinomas and 770 matched controls. Twenty common polymorphisms at cytokine genes [interleukin (IL)1A, IL1B, IL1RN, IL4, IL4R, IL6, IL8, IL10, IL12A, IL12B, lymphotoxin α and tumor necrosis factor (TNF)] were analyzed. Antibodies against Helicobacter pylori (Hp) and CagA were measured. Results: IL1RN 2R/2R genotype [odds ratio (OR) 2.43; 95% confidence interval (CI) 1.19â4.96] and allele IL1RN Ex5â35C were associated with an increased risk of Hp() non-cardia GC. IL8 â251AA genotype was associated with a decreased risk of Hp() non-cardia GC (OR 0.51; 95% CI 0.32â0.81), mainly of the intestinal type. These associations were not modified by CagA status. Carriers of IL1B â580C and TNF â487A alleles did not associate with an increased risk. A moderately increased risk of Hp() non-cardia GC for IL4R â29429T variant was observed (OR 1.74; 95% CI 1.15â2.63). Conclusion: This prospective study confirms the association of IL1RN polymorphisms with the risk of non-cardia GC and indicates that IL8 â251T>A may modify the risk for GC. [ABSTRACT FROM AUTHOR] |
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