Bibliographic Details
| Title: |
STUDY ON THE EVALUATION OF PLASMA FACTOR XIII ACTIVITY. |
| Authors: |
Dican, Lucia1, Lucaciu, Roxana2, Cucuianu, M.1 |
| Source: |
Annals of West University of Timisoara: Series of Chemistry. 2007, Vol. 16 Issue 2, p155-162. 8p. |
| Subject Terms: |
*BLOOD coagulation factor XIII, *MYOCARDIAL infarction, *PHOTOMETRY, *CHOLINESTERASES, *ACUTE phase proteins |
| Abstract: |
Factor XIII (FXIII) of blood coagulation present in plasma is a transglutaminase of tetrameric structure. FXIII, when activated by thrombin, covalently crosslinks fibrin multimer strands, thereby enhancing the mechanical stregth of clot and increasing the resistance to fibrinolysis. This study aims to evaluate behaviour factor XIII activity in patients affected by an acute myocardial infarction. The 31 investigated subjects were divided into the following groups: Normal weight, normolipidemic control subjects; Acute myocardial infarction (AMI); Factor XIII activity was measured by a photometric assay using standardized reagents. Plasma fibrinogen level was obviously increased, while plasma factor XIII and serum cholinesterase (CHE) activity activities appeared to be decreased in patient with AMI. In our opinion a cytokine induced acute phase reaction would switch the pattern of hepatic protein synthesis, resulting in increased production of acute phase reactants, while reducing the synthesis of other liver derived protein such as CHE and FXIII. [ABSTRACT FROM AUTHOR] |
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