Bibliographic Details
| Title: |
Effect of Infliximab on Experimentally Induced Otitis Media in Rats. |
| Authors: |
Dong-Hee Lee1, Sang-Won Yeo1, Ki-Hong Chang1, So-Young Park1, Jeong-Hoon Oh1, Jae-Hyun Seo1 |
| Source: |
Annals of Otology, Rhinology & Laryngology. Jun2008, Vol. 117 Issue 6, p470-476. 7p. |
| Subject Terms: |
*EAR diseases, *MIDDLE ear diseases, *OTITIS media, *GROWTH factors, *MUCOUS membranes, *TUMOR necrosis factors |
| Abstract: |
Objectives: We performed a prospective randomized and controlled animal study to investigate the effects of infliximab on experimental otitis media in rats. Methods: Seventy-two Sprague-Dawley rats were randomly allocated to 3 study groups and 1 control group. Infliximab was injected intravenously. Histopathologic changes were determined by hematoxylin-eosin staining. Fluorescence microscopy was performed to examine the leakage of the exudates. Vascular permeability was measured by the Evans blue dye technique. Results: In comparison with the control group, we found significant differences in the extent of middle ear mucosa without active inflammation and the presence of reparable lesions in all study groups treated with infliximab. A significant reduction of extravasated Evans blue dye in all study group animals was found as compared with the control group animals. Conclusions: This study suggests that the monoclonal tumor necrosis factor α antibody, infliximab, can reduce inflammatory activity in experimental otitis media in rats. [ABSTRACT FROM AUTHOR] |
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| Database: |
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