Bibliographic Details
| Title: |
The B Cell Inhibitory Fc Receptor Triggers Apoptosis by a Novel c-Abl Family Kinase-dependent Pathway. |
| Authors: |
Shiang-Jong Tzeng1, Bolland, Silvia1, Inabe, Kazunori2, Kurosaki, Tomohiro3, Pierce, Susan K.1 spierce@nih.gov |
| Source: |
Journal of Biological Chemistry. 10/21/2005, Vol. 280 Issue 42, p35247-35254. 8p. 7 Graphs. |
| Subject Terms: |
*B cells, *ANTIGEN presenting cells, *PROTEIN-tyrosine kinases, *CELL receptors, *LYMPHOCYTES, *PHOSPHATASES, *APOPTOSIS |
| Abstract: |
The inhibitory Fc receptors function to regulate the antigen-driven activation and expansion of lymphocytes. In B cells, the FcγRIIB1 is a potent inhibitor of B cell antigen receptor (BCR) signaling when coligated to the BCR by engagement of antigen-containing immune complexes. Inhibition is mediated by the recruitment of the inositol phosphatase, SHIP, to the FcγRIIB1 phosphorylated tyrosine-based inhibitory motif (ITIM). Here we show that BCR-independent aggregation of the FcγRIIB1 transduces an ITIM- and SHIP-independent proapoptotic signal that is dependent on members of the c-Abl tyrosine kinase family. These results define a novel Abl family kinase-dependent FcγRIIB1 signaling pathway that functions independently of the BCR in controlling antigen-driven B cell responses. [ABSTRACT FROM AUTHOR] |
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| Database: |
Academic Search Complete |
