| Title: |
A function for interleukin 2 in Foxp3-expressing regulatory T cells. |
| Authors: |
Fontenot, Jason D.1,2 jfontenot@rockefeller.edu, Rasmussen, Jeffrey P.1, Gavin, Marc A.1, Rudensky, Alexander Y.1 |
| Source: |
Nature Immunology. Nov2005, Vol. 6 Issue 11, p1142-1151. 10p. 1 Diagram, 6 Graphs. |
| Subject Terms: |
*T cells, *INTERLEUKIN-2, *IMMUNOMODULATORS, *CELLULAR control mechanisms, *CELL proliferation, *PHYSIOLOGICAL control systems |
| Abstract: |
Regulatory T cells (Treg cells) expressing the forkhead family transcription factor Foxp3 are critical mediators of dominant immune tolerance to self. Most Treg cells constitutively express the high-affinity interleukin 2 (IL-2) receptor α-chain (CD25); however, the precise function of IL-2 in Treg cell biology has remained controversial. To directly assess the effect of IL-2 signaling on Treg cell development and function, we analyzed mice containing the Foxp3gfp knock-in allele that were genetically deficient in either IL-2 (Il2−/−) or CD25 (Il2ra−/−). We found that IL-2 signaling was dispensable for the induction of Foxp3 expression in thymocytes from these mice, which indicated that IL-2 signaling does not have a nonredundant function in the development of Treg cells. Unexpectedly, Il2−/− and Il2ra−/− Treg cells were fully able to suppress T cell proliferation in vitro. In contrast, Foxp3 was not expressed in thymocytes or peripheral T cells from Il2rg−/− mice. Gene expression analysis showed that IL-2 signaling was required for maintenance of the expression of genes involved in the regulation of cell growth and metabolism. Thus, IL-2 signaling seems to be critically required for maintaining the homeostasis and competitive fitness of Treg cells in vivo. [ABSTRACT FROM AUTHOR] |
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