Bibliographic Details
| Title: |
Platelet-Sourced TGF-β Promotes Th17 Responses and Enhances Airway Neutrophilia. |
| Authors: |
Wang, Ruoning1 (AUTHOR), Wu, Dandan1,2 (AUTHOR), Wang, Chunqing2,3 (AUTHOR), Livingston, Amanda1 (AUTHOR), Wu, Xiang1,2,3 (AUTHOR), Liu, Meilian2,3 (AUTHOR), Yang, Xuexian O.1 (AUTHOR) xyang@salud.unm.edu |
| Source: |
Biomolecules (2218-273X). Apr2025, Vol. 15 Issue 4, p482. 16p. |
| Abstract: |
Microbial, especially fungal, sensitization has been associated with the development and exacerbation of treatment-refractory neutrophilic asthma. Among the airway-inhabiting fungi, Aspergillus fumigatus and Candida albicans are the dominant species that elicit protective T helper (Th) 17 and other T cell responses, contributing to airway neutrophilia and steroid resistance. However, it is not fully understood how fungal airway colonization impacts the immunopathogenesis of asthma. Here, we used a neutrophilic asthma model induced by C. albicans to study the immune regulation of this disease. We found that intranasal administration of C. albicans induced platelet infiltration into the lung. Platelet-expressed latent TGF-β could be activated specifically by Th17 cells and drive the commitment, maintenance, and expansion of Th17 cells. In Candida-induced asthma, an adoptive transfer of platelets enhanced Th17 responses, increasing airway neutrophil influx. Thus, managing airway mycobiota and reducing platelet intrapulmonary infiltration may serve as a promising interventional approach. [ABSTRACT FROM AUTHOR] |
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