Bibliographic Details
| Title: |
Epidemiological and clinical profile of toxidermia at the Departmental University Hospital Center of Borgou/Alibori, Benin. |
| Authors: |
Akpadjan, Fabrice1,2 barfice@yahoo.fr, Agbessi, Nadège2, Dotsop, Laura1,3, Koudoukpo, Christiane3 |
| Source: |
Our Dermatology Online / Nasza Dermatologia Online. Apr2025, Vol. 16 Issue 2, p136-140. 5p. |
| Subject Terms: |
*DRUG eruptions, *STEVENS-Johnson Syndrome, *DRUG side effects, *DERMATOLOGY, *SYMPTOMS, *EPIDEMIOLOGY |
| Geographic Terms: |
BENIN |
| Abstract: |
Background: Toxidermias are adverse skin reactions caused by medications administered systemically. They cover a wide range of clinical presentations corresponding to different pathophysiological mechanisms. The aim was to study the epidemiological and clinical profile of these drug eruptions at a university hospital in northern Benin. Patients and Methods: This was a cross-sectional, descriptive study based on the medical records of patients seen in dermatology consultations for drug eruptions from January 2009 to June 2022 at the Departmental University Hospital Center of Borgou/Alibori (DUHC-B/A). Epidemiological and clinical data was recorded and analyzed using EpiData 3.1 and IBM SPSS Statistics 21. Results: Out of 8,829 patients, 123 cases of drug eruptions were recorded, resulting in a hospital frequency of 1.39%. The average age of the patients was 33.9 ± 20.7 years, with a range of 1 to 90 years. The male-to-female ratio was 0.98. The most implicated drugs were cotrimoxazole (13.0%), followed by paracetamol (12.2%), amoxicillin (4.9%), and artemether-lumefantrine (4.9%). The time between drug intake and symptom onset ranged from 1 to 7 days in 13.0% of the patients. Fixed drug eruption (FDE) was the most frequent benign drug eruption (52.0%), while Stevens--Johnson syndrome (SJS) was the most frequent severe drug eruption (17.1%). Conclusion: The hospital frequency of drug eruptions was relatively low at the Dermatology and Venereology Unit of DUHC-B/A. Sulfonamides, analgesics, and antimalarials were the most implicated drug categories. The majority of drug eruptions were benign, with FDE being the most common, while SJS was the most frequent severe form. [ABSTRACT FROM AUTHOR] |
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